Structural aspects of the MHC expression control system
G Nash, B Paidimuddala, L Zhang - Biophysical chemistry, 2022 - Elsevier
The major histocompatibility complex (MHC) spans innate and adaptive immunity by
presenting antigenic peptides to CD4+ and CD8+ T cells. Multiple transcription factors form
an enhanceosome complex on the MHC promoter and recruit transcriptional machinery to
activate gene transcription. Immune signals such as interferon-γ (IFN-γ) control MHC level
by up-regulating components of the enhanceosome complex. As MHC plays crucial roles in
immune regulation, alterations in the MHC enhanceosome structure will alter the pace of …
presenting antigenic peptides to CD4+ and CD8+ T cells. Multiple transcription factors form
an enhanceosome complex on the MHC promoter and recruit transcriptional machinery to
activate gene transcription. Immune signals such as interferon-γ (IFN-γ) control MHC level
by up-regulating components of the enhanceosome complex. As MHC plays crucial roles in
immune regulation, alterations in the MHC enhanceosome structure will alter the pace of …
