TET family dioxygenases and the TET activator vitamin C in immune responses and cancer
X Yue, A Rao - Blood, The Journal of the American Society of …, 2020 - ashpublications.org
X Yue, A Rao
Blood, The Journal of the American Society of Hematology, 2020•ashpublications.orgVitamin C serves as a cofactor for Fe (II) and 2-oxoglutarate–dependent dioxygenases
including TET family enzymes, which catalyze the oxidation of 5-methylcytosine into 5-
hydroxymethylcytosine and further oxidize methylcytosines. Loss-of-function mutations in
epigenetic regulators such as TET genes are prevalent in hematopoietic malignancies.
Vitamin C deficiency is frequently observed in cancer patients. In this review, we discuss the
role of vitamin C and TET proteins in cancer, with a focus on hematopoietic malignancies, T …
including TET family enzymes, which catalyze the oxidation of 5-methylcytosine into 5-
hydroxymethylcytosine and further oxidize methylcytosines. Loss-of-function mutations in
epigenetic regulators such as TET genes are prevalent in hematopoietic malignancies.
Vitamin C deficiency is frequently observed in cancer patients. In this review, we discuss the
role of vitamin C and TET proteins in cancer, with a focus on hematopoietic malignancies, T …
Abstract
Vitamin C serves as a cofactor for Fe(II) and 2-oxoglutarate–dependent dioxygenases including TET family enzymes, which catalyze the oxidation of 5-methylcytosine into 5-hydroxymethylcytosine and further oxidize methylcytosines. Loss-of-function mutations in epigenetic regulators such as TET genes are prevalent in hematopoietic malignancies. Vitamin C deficiency is frequently observed in cancer patients. In this review, we discuss the role of vitamin C and TET proteins in cancer, with a focus on hematopoietic malignancies, T regulatory cells, and other immune system cells.
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