[HTML][HTML] TNFR2 interposes the proliferative and NF-κB-mediated inflammatory response by podocytes to TNF-α
LA Bruggeman, PE Drawz, N Kahoud, K Lin… - Laboratory …, 2011 - Elsevier
The development of proliferative podocytopathies has been linked to ligation of tumor
necrosis factor receptor 2 (TNFR2) expressed on the renal parenchyma; however, the
TNFR2-positive cells within the kidney responsible for podocyte injury are unknown. We
detected de novo expression of TNFR2 on podocytes before hyperplastic injury in crescentic
glomerulonephritis of mice with nephrotoxic nephritis, and in collapsing glomerulopathy of
Tg26 HIV/nl mice, kd/kd mice, and human beings. We further found that serum levels of …
necrosis factor receptor 2 (TNFR2) expressed on the renal parenchyma; however, the
TNFR2-positive cells within the kidney responsible for podocyte injury are unknown. We
detected de novo expression of TNFR2 on podocytes before hyperplastic injury in crescentic
glomerulonephritis of mice with nephrotoxic nephritis, and in collapsing glomerulopathy of
Tg26 HIV/nl mice, kd/kd mice, and human beings. We further found that serum levels of …