Truncated plasminogen activator inhibitor-1 protein protects from pulmonary fibrosis mediated by irradiation in a murine model
EJ Chung, G McKay-Corkum, S Chung, A White… - International Journal of …, 2016 - Elsevier
Purpose To determine whether the delivery of recombinant truncated plasminogen activator
inhibitor-1 (PAI-1) protein (rPAI-1 23) would protect from the development of radiation-
induced lung injury. Methods and Materials C57Bl/6 mice received intraperitoneal injections
of rPAI-1 23 (5.4 μg/kg/d) or vehicle for 18 weeks, beginning 2 days before irradiation (IR)(5
daily fractions of 6 Gy). Cohorts of mice were followed for survival (n= 8 per treatment) and
tissue collection (n= 3 per treatment and time point). Fibrosis in lung was assessed with …
inhibitor-1 (PAI-1) protein (rPAI-1 23) would protect from the development of radiation-
induced lung injury. Methods and Materials C57Bl/6 mice received intraperitoneal injections
of rPAI-1 23 (5.4 μg/kg/d) or vehicle for 18 weeks, beginning 2 days before irradiation (IR)(5
daily fractions of 6 Gy). Cohorts of mice were followed for survival (n= 8 per treatment) and
tissue collection (n= 3 per treatment and time point). Fibrosis in lung was assessed with …
