[HTML][HTML] Diet-induced elevation of circulating HSP70 may trigger cell adhesion and promote the development of atherosclerosis in rats
F Xie, R Zhan, LC Yan, JB Gong, Y Zhao, J Ma… - Cell stress and …, 2016 - Elsevier
Although accumulating evidence indicates that heat shock protein 70 (HSP70) could be
secreted into plasma and its levels have been found to have an ambiguous association with
atherosclerosis, our knowledge for the exact role of circulating HSP70 in the development of
atherosclerosis is still limited. In the present study, we report an adhesion-promoting effect of
exogenous HSP70 and evaluate the potential involvement of elevated circulating HSP70 in
the development of atherosclerosis. Time-dependent elevation of plasma HSP70 was found …
secreted into plasma and its levels have been found to have an ambiguous association with
atherosclerosis, our knowledge for the exact role of circulating HSP70 in the development of
atherosclerosis is still limited. In the present study, we report an adhesion-promoting effect of
exogenous HSP70 and evaluate the potential involvement of elevated circulating HSP70 in
the development of atherosclerosis. Time-dependent elevation of plasma HSP70 was found …