[HTML][HTML] Extracellular Hsp70 induces inflammation and modulates LPS/LTA-stimulated inflammatory response in THP-1 cells
Abstract Extracellular Hsp70 (eHsp70) can act as damage-associated molecular pattern
(DAMP) via Toll-like receptors TLR2 and TLR4, and stimulate immune and inflammatory
responses leading to sterile inflammation and propagation of already existing inflammation.
It was found elevated in the blood of patients with chronic obstructive pulmonary disease
(COPD), who might suffer occasional bacterial colonizations and infections. We used a
monocytic THP-1 cell line as a cellular model of systemic compartment of COPD to assess …
(DAMP) via Toll-like receptors TLR2 and TLR4, and stimulate immune and inflammatory
responses leading to sterile inflammation and propagation of already existing inflammation.
It was found elevated in the blood of patients with chronic obstructive pulmonary disease
(COPD), who might suffer occasional bacterial colonizations and infections. We used a
monocytic THP-1 cell line as a cellular model of systemic compartment of COPD to assess …
