Synovial cell activation

J Stanczyk, C Ospelt, RE Gay… - Current opinion in …, 2006 - journals.lww.com
J Stanczyk, C Ospelt, RE Gay, S Gay
Current opinion in rheumatology, 2006journals.lww.com
The key role of synovial fibroblasts in the pathogenesis of rheumatoid arthritis has been
highlighted by the fact that these cells not only are the main executors of cartilage and bone
destruction but also modulate numerous interactions in rheumatoid joints. Moreover, it has
become evident that integration of a large body of information is indispensable to get a
comprehensive outlook on synovial activation in the pathology of rheumatoid arthritis.
Summary
The key role of synovial fibroblasts in the pathogenesis of rheumatoid arthritis has been highlighted by the fact that these cells not only are the main executors of cartilage and bone destruction but also modulate numerous interactions in rheumatoid joints. Moreover, it has become evident that integration of a large body of information is indispensable to get a comprehensive outlook on synovial activation in the pathology of rheumatoid arthritis.
Lippincott Williams & Wilkins