The function of BAFF on T helper cells in autoimmunity
M Chen, X Lin, Y Liu, Q Li, Y Deng, Z Liu… - Cytokine & growth factor …, 2014 - Elsevier
B cell-activating factor belonging to the TNF family (BAFF) exerts its pathogenic role in
supporting the survival and proliferation of B cells, regulating class switch recombination as
well as the selection of autoreactive B cells. Overexpression of BAFF induces a dramatic
expansion of activated B cells, particularly marginal zone B cells, as well as
hypergammaglobulinemia, autoantibody production and immune complex deposition.
However, in addition to its effect on B cells, recent work has also demonstrated that BAFF …
supporting the survival and proliferation of B cells, regulating class switch recombination as
well as the selection of autoreactive B cells. Overexpression of BAFF induces a dramatic
expansion of activated B cells, particularly marginal zone B cells, as well as
hypergammaglobulinemia, autoantibody production and immune complex deposition.
However, in addition to its effect on B cells, recent work has also demonstrated that BAFF …