Regulatory activities of 2β-(3-hydroxypropoxy)-1α, 25-dihydroxyvitamin D3, a novel synthetic vitamin D3 derivative, on calcium metabolism
T Okano, N Tsugawa, S Masuda, A Takeuchi… - Biochemical and …, 1989 - Elsevier
T Okano, N Tsugawa, S Masuda, A Takeuchi, T Kobayashi, Y Takita, Y Nishii
Biochemical and biophysical research communications, 1989•ElsevierAbstract Regulatory activities of 2β-(3-hydroxypropoxy)-1α, 25-dihydroxyvitamin D 3 [ED-71],
a novel synthetic vitamin D 3 derivative, on calcium metabolism were investigated. The
compound behaved similar to 1α, 25-dihydroxyvitamin D 3 [1, 25 (OH) 2 D 3] in the ex vivo
intestinal calcium transport using rat everted gut sac and the in vivo bone mobilization using
vitamin D-deficient rats. By means of Raisz's assay method, 45 Ca releasing activity of ED-
71 was not greater than that of 1, 25 (OH) 2 D 3. The time course curve of ED-71 in plasma …
a novel synthetic vitamin D 3 derivative, on calcium metabolism were investigated. The
compound behaved similar to 1α, 25-dihydroxyvitamin D 3 [1, 25 (OH) 2 D 3] in the ex vivo
intestinal calcium transport using rat everted gut sac and the in vivo bone mobilization using
vitamin D-deficient rats. By means of Raisz's assay method, 45 Ca releasing activity of ED-
71 was not greater than that of 1, 25 (OH) 2 D 3. The time course curve of ED-71 in plasma …
Abstract
Abstract Regulatory activities of 2β-(3-hydroxypropoxy)-1α, 25-dihydroxyvitamin D 3 [ED-71], a novel synthetic vitamin D 3 derivative, on calcium metabolism were investigated. The compound behaved similar to 1α, 25-dihydroxyvitamin D 3 [1, 25 (OH) 2 D 3] in the ex vivo intestinal calcium transport using rat everted gut sac and the in vivo bone mobilization using vitamin D-deficient rats. By means of Raisz's assay method, 45 Ca releasing activity of ED-71 was not greater than that of 1, 25 (OH) 2 D 3. The time course curve of ED-71 in plasma made a mild round shape compared with that of 1, 25 (OH) 2 D 3 and the former's plasma concentration remained increased longer than the latter's. The therapeutic effect of ED-71 for the animal models with osteoporosis seemed to be better than that of 1, 25 (OH) 2 D 3. The results suggest that ED-71 may be a promising drug for therapy of osteoporosis.
Elsevier