[HTML][HTML] Recurrence of heterotopic ossification after removal in patients with traumatic brain injury: a systematic review
W Almangour, A Schnitzler, M Salga, C Debaud… - Annals of physical and …, 2016 - Elsevier
W Almangour, A Schnitzler, M Salga, C Debaud, P Denormandie, F Genêt
Annals of physical and rehabilitation medicine, 2016•ElsevierObjective A systematic review of the literature to determine whether in patients with
neurological heterotopic ossification (NHO) after traumatic brain injury, the extent of the
neurological sequelae, the timing of surgery and the extent of the initial NHO affect the risk of
NHO recurrence. Data sources We searched MEDLINE via PubMed and Cochrane library
for articles published up to June 2015. Results were compared with epidemiological studies
using data from the BANKHO database of 357 patients with central nervous system (CNS) …
neurological heterotopic ossification (NHO) after traumatic brain injury, the extent of the
neurological sequelae, the timing of surgery and the extent of the initial NHO affect the risk of
NHO recurrence. Data sources We searched MEDLINE via PubMed and Cochrane library
for articles published up to June 2015. Results were compared with epidemiological studies
using data from the BANKHO database of 357 patients with central nervous system (CNS) …
Objective
A systematic review of the literature to determine whether in patients with neurological heterotopic ossification (NHO) after traumatic brain injury, the extent of the neurological sequelae, the timing of surgery and the extent of the initial NHO affect the risk of NHO recurrence.
Data sources
We searched MEDLINE via PubMed and Cochrane library for articles published up to June 2015. Results were compared with epidemiological studies using data from the BANKHO database of 357 patients with central nervous system (CNS) lesions who underwent 539 interventions for troublesome HO.
Results
A large number of studies were published in the 1980s and 1990s, most showing poor quality despite being performed by experienced surgical teams. Accordingly, results were contradictory and practices heterogeneous. Results with the BANKHO data showed troublesome NHO recurrence not associated with aetiology, sex, age at time of CNS lesion, multisite HO, or “early” surgery (before 6 months). Equally, recurrence was not associated with neurological sequelae or disease extent around the joint.
Conclusions
The recurrence of NHO is not affected by delayed surgery, neurological sequelae or disease extent around the joint. Surgical excision of NHO should be performed as soon as comorbid factors are under control and the NHO is sufficiently constituted for excision.
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