The dual role of IL-6-type cytokines on bone remodeling and bone tumors
F Blanchard, L Duplomb, M Baud'huin… - Cytokine & growth factor …, 2009 - Elsevier
Many factors such as vitamins, hormones and cytokines, control bone metabolism and
remodeling. Cytokines of the interleukin-6 family, by acting on bone cells (ie osteoblasts and
osteoclasts), have an important role in the bone tissue but they recently appeared as double-
edged swords. They sustain bone formation but they can also drive bone loss in various
osteolytic pathologies. Similarly, development of bone cancers can be either prevented or
enhanced by these cytokines, depending on the cell type, the stage of the tumor and the …
remodeling. Cytokines of the interleukin-6 family, by acting on bone cells (ie osteoblasts and
osteoclasts), have an important role in the bone tissue but they recently appeared as double-
edged swords. They sustain bone formation but they can also drive bone loss in various
osteolytic pathologies. Similarly, development of bone cancers can be either prevented or
enhanced by these cytokines, depending on the cell type, the stage of the tumor and the …