A central feature of obesity-related cardiometabolic diseases is the impaired ability to
transition between fatty acid and glucose metabolism. This impairment, referred to as
“metabolic inflexibility”, occurs in a number of tissues, including the heart. Although the heart
normally prefers to metabolize fatty acids over glucose, the inability to upregulate glucose
metabolism under energetically demanding conditions contributes to a pathological state
involving energy imbalance, impaired contractility, and post-translational protein …