Specific involvement in neuropathic pain of AMPA receptors and adapter proteins for the GluR2 subunit
EM Garry, A Moss, R Rosie, A Delaney… - Molecular and Cellular …, 2003 - Elsevier
Chronic pain states arise from peripheral nerve injury and are inadequately treated with
current analgesics. Using intrathecal drug administration in a rat model of neuropathic pain,
we demonstrate that AMPA receptors play a role in the central sensitisation that is thought to
underpin chronic pain. The GluR2 subunit of the AMPA receptor binds to a number of
intracellular adapter proteins including GRIP, PICK1 and NSF, which may link the receptor to
proteins with signalling, scaffolding and other roles. We implicate for the first time a possible …
current analgesics. Using intrathecal drug administration in a rat model of neuropathic pain,
we demonstrate that AMPA receptors play a role in the central sensitisation that is thought to
underpin chronic pain. The GluR2 subunit of the AMPA receptor binds to a number of
intracellular adapter proteins including GRIP, PICK1 and NSF, which may link the receptor to
proteins with signalling, scaffolding and other roles. We implicate for the first time a possible …
