[HTML][HTML] The antibacterial properties of secreted phospholipases A2: a major physiological role for the group IIA enzyme that depends on the very high pI of the …
The antibacterial properties of human group IIA secreted phospholipase A 2 against Gram-
positive bacteria as a result of membrane hydrolysis have been reported. Using Micrococcus
luteus as a model system, we demonstrate the very high specificity of this human enzyme for
such hydrolysis compared with the group IB, IIE, IIF, V, and X human secreted
phospholipase A 2 s. A unique feature of the group IIA enzyme is its very high pI due to a
large excess of cationic residues on the enzyme surface. The importance of this global …
positive bacteria as a result of membrane hydrolysis have been reported. Using Micrococcus
luteus as a model system, we demonstrate the very high specificity of this human enzyme for
such hydrolysis compared with the group IB, IIE, IIF, V, and X human secreted
phospholipase A 2 s. A unique feature of the group IIA enzyme is its very high pI due to a
large excess of cationic residues on the enzyme surface. The importance of this global …