[HTML][HTML] Tissue-resident memory T cells in the multiple sclerosis brain and their relationship to Epstein-Barr virus infected B cells
B Serafini, B Rosicarelli, C Veroni, F Aloisi - Journal of Neuroimmunology, 2023 - Elsevier
Presence of EBV infected B cells and EBV-specific CD8 T cells in the multiple sclerosis (MS)
brain suggests a role for virus-driven immunopathology in brain inflammation. Tissue-
resident memory (Trm) T cells differentiating in MS lesions could provide local protection
against EBV reactivation. Using immunohistochemical techniques to analyse canonical
tissue residency markers in postmortem brains from control and MS cases, we report that
CD103 and/or CD69 are mainly expressed in a subset of CD8+ T cells that intermingle with …
brain suggests a role for virus-driven immunopathology in brain inflammation. Tissue-
resident memory (Trm) T cells differentiating in MS lesions could provide local protection
against EBV reactivation. Using immunohistochemical techniques to analyse canonical
tissue residency markers in postmortem brains from control and MS cases, we report that
CD103 and/or CD69 are mainly expressed in a subset of CD8+ T cells that intermingle with …
