Various PfRH5 polymorphisms can support Plasmodium falciparum invasion into the erythrocytes of owl monkeys and rats

K Hayton, P Dumoulin, B Henschen, A Liu… - Molecular and …, 2013 - Elsevier
Aotus nancymaae, the owl monkey, provides a useful laboratory model for research to
develop drugs and vaccines against human falciparum malaria; however, many
Plasmodium falciparum parasites are unable to invade A. nancymaae erythrocytes,
rendering the parasites noninfective to the monkeys. In previous work, we identified a key
polymorphism that determined the inheritance of erythrocyte invasion in a genetic cross of
two P. falciparum clones that were virulent (GB4) or noninfective (7G8) to A. nancymaae …