Scalp and serum profiling of frontal fibrosing alopecia reveals scalp immune and fibrosis dysregulation with no systemic involvement
C Dubin, JW Glickman, E Del Duca… - Journal of the American …, 2022 - Elsevier
Background Frontal fibrosing alopecia (FFA) is a progressive, scarring alopecia of the
frontotemporal scalp that poses a substantial burden on quality of life. Large-scale global
profiling of FFA is lacking, preventing the development of effective therapeutics. Objective To
characterize FFA compared to normal and alopecia areata using broad molecular profiling
and to identify biomarkers linked to disease severity. Methods This cross-sectional study
assessed 33,118 genes in scalp using RNA sequencing and 350 proteins in serum using …
frontotemporal scalp that poses a substantial burden on quality of life. Large-scale global
profiling of FFA is lacking, preventing the development of effective therapeutics. Objective To
characterize FFA compared to normal and alopecia areata using broad molecular profiling
and to identify biomarkers linked to disease severity. Methods This cross-sectional study
assessed 33,118 genes in scalp using RNA sequencing and 350 proteins in serum using …
