[HTML][HTML] Desmoglein-1 regulates esophageal epithelial barrier function and immune responses in eosinophilic esophagitis

JD Sherrill, K Kc, D Wu, Z Djukic, JM Caldwell… - Mucosal …, 2014 - Elsevier
The desmosomal cadherin desmoglein-1 (DSG1) is an essential intercellular adhesion
molecule that is altered in various human cutaneous disorders; however, its regulation and
function in allergic disease remains unexplored. Herein, we demonstrate a specific
reduction in DSG1 in esophageal biopsies from patients with eosinophilic esophagitis (EoE),
an emerging allergic disorder characterized by chronic inflammation within the esophageal
mucosa. Further, we show that DSG1 gene silencing weakens esophageal epithelial …