The mammalian circadian timing system: organization and coordination of central and peripheral clocks

C Dibner, U Schibler, U Albrecht - Annual review of physiology, 2010 - annualreviews.org
Most physiology and behavior of mammalian organisms follow daily oscillations. These
rhythmic processes are governed by environmental cues (eg, fluctuations in light intensity
and temperature), an internal circadian timing system, and the interaction between this
timekeeping system and environmental signals. In mammals, the circadian timekeeping
system has a complex architecture, composed of a central pacemaker in the brain's
suprachiasmatic nuclei (SCN) and subsidiary clocks in nearly every body cell. The central …