Neurexophilin binding to α-Neurexins: a single LNS domain functions as an independently folding ligand-binding unit
M Missler, RE Hammer, TC Sudhof - Journal of Biological Chemistry, 1998 - jbc.org
α-Neurexins (Iα, IIα, and IIIα) are receptor-like proteins expressed in hundreds of isoforms on
the neuronal cell surface. The extracellular domains of α-neurexins are composed of six
LNS repeats, named after homologous sequences in theLaminin AG domain, Neurexins,
andSex hormone-binding globulin, with three interspersed epidermal growth factor-like
domains. Purification of neurexin Iα revealed that it is tightly complexed to a secreted
glycoprotein called neurexophilin 1. Neurexophilin 1 is a member of a family of at least four …
the neuronal cell surface. The extracellular domains of α-neurexins are composed of six
LNS repeats, named after homologous sequences in theLaminin AG domain, Neurexins,
andSex hormone-binding globulin, with three interspersed epidermal growth factor-like
domains. Purification of neurexin Iα revealed that it is tightly complexed to a secreted
glycoprotein called neurexophilin 1. Neurexophilin 1 is a member of a family of at least four …
