Animal models of mood disorders: recent developments

JF Cryan, DA Slattery - Current opinion in psychiatry, 2007 - journals.lww.com
Current opinion in psychiatry, 2007journals.lww.com
Endophenotype-based modelling of depression and bipolar illness is opening up more
tractable avenues for understanding the neurobiological and genetic bases of these
disorders. Further, advances in the clinical dissection of the psychiatric illnesses using
molecular genetics, coupled with functional neuroimaging techniques, promises to yield
better translational animal models and hence more fruitful therapeutic targets.
Summary
Endophenotype-based modelling of depression and bipolar illness is opening up more tractable avenues for understanding the neurobiological and genetic bases of these disorders. Further, advances in the clinical dissection of the psychiatric illnesses using molecular genetics, coupled with functional neuroimaging techniques, promises to yield better translational animal models and hence more fruitful therapeutic targets.
Lippincott Williams & Wilkins