Differential expression and dendritic transcript localization of Shank family members: identification of a dendritic targeting element in the 3′ untranslated region of …
TM Böckers, M Segger-Junius, P Iglauer… - Molecular and Cellular …, 2004 - Elsevier
Shank proteins are scaffolding proteins in the postsynaptic density of excitatory synapses in
the mammalian brain. In situ hybridization revealed that Shank1/SSTRIP and
Shank2/ProSAP1 mRNAs are widely expressed early in postnatal brain development
whereas Shank3/ProSAP2 expression increases during postnatal development especially in
the cerebellum and thalamus. Shank1 and Shank3 (but not Shank2) mRNAs are present in
the molecular layers of the hippocampus, consistent with a dendritic transcript localization …
the mammalian brain. In situ hybridization revealed that Shank1/SSTRIP and
Shank2/ProSAP1 mRNAs are widely expressed early in postnatal brain development
whereas Shank3/ProSAP2 expression increases during postnatal development especially in
the cerebellum and thalamus. Shank1 and Shank3 (but not Shank2) mRNAs are present in
the molecular layers of the hippocampus, consistent with a dendritic transcript localization …