Context Bipolar mania and schizophrenia are recognized as separate disorders but share
many commonalities, which raises the question of whether they are the same disorder on
different ends of a continuum. The lack of distinct endophenotypes of bipolar mania and
schizophrenia has complicated the development of animal models that are specific to these
disorders. Exploration is fundamental to survival and is dysregulated in these 2 disorders.
Although exploratory behavior in rodents has been widely studied, surprisingly little work …