Detection and assignment of the glucose signal in 1h nmr difference spectra of the human brain

R Gruetter, DL Rothman, EJ Novotny… - Magnetic resonance …, 1992 - Wiley Online Library
R Gruetter, DL Rothman, EJ Novotny, GI Shulman, JW Prichard, RG Shulman
Magnetic resonance in medicine, 1992Wiley Online Library
The difference between 1H NMR spectra obtained during eu‐and hyperglycemia exhibited
well‐resolved glucose peaks between 3 and 4 ppm as demonstrated by comparison with
solution spectra. Estimated increases were consistent with recent 13C NMR quantitations of
intracerebral glucose. Difference spectra were measured in 36‐ml volumes from the human
brain every 3 min.
Abstract
The difference between 1H NMR spectra obtained during eu‐ and hyperglycemia exhibited well‐resolved glucose peaks between 3 and 4 ppm as demonstrated by comparison with solution spectra. Estimated increases were consistent with recent 13C NMR quantitations of intracerebral glucose. Difference spectra were measured in 36‐ml volumes from the human brain every 3 min.
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