Sepsis is expected to have a substantial impact on public health and cost as its prevalence
increases. Factors contributing to increased prevalence include a progressively aging
population, advances in the use of immunomodulatory agents to treat a rising number of
diseases, and immune-suppressing therapies in organ transplant recipients and cancer
patients. It is now recognized that sepsis is associated with profound and sustained
immunosuppression, which has been implicated as a predisposing factor in the increased …