[HTML][HTML] Endothelial Jarid2/Jumonji is required for normal cardiac development and proper Notch1 expression
MR Mysliwiec, EH Bresnick, Y Lee - Journal of Biological Chemistry, 2011 - ASBMB
Jarid2/Jumonji critically regulates developmental processes including cardiovascular
development. Jarid2 knock-out mice exhibit cardiac defects including hypertrabeculation
with noncompaction of the ventricular wall. However, molecular mechanisms underlying
Jarid2-mediated cardiac development remain unknown. To determine the cardiac lineage-
specific roles of Jarid2, we generated myocardial, epicardial, cardiac neural crest, or
endothelial conditional Jarid2 knock-out mice using Cre-loxP technology. Only mice with an …
development. Jarid2 knock-out mice exhibit cardiac defects including hypertrabeculation
with noncompaction of the ventricular wall. However, molecular mechanisms underlying
Jarid2-mediated cardiac development remain unknown. To determine the cardiac lineage-
specific roles of Jarid2, we generated myocardial, epicardial, cardiac neural crest, or
endothelial conditional Jarid2 knock-out mice using Cre-loxP technology. Only mice with an …