Genetic and developmental basis of cardiovascular malformations

M Azhar, SM Ware - Clinics in perinatology, 2016 - perinatology.theclinics.com
The underlying causes of cardiovascular malformations (CVMs) can include cytogenetic
abnormalities, single-gene disorders, environmental causes, or (most commonly) the causes
can be multifactorial (Table 1). Chromosomal abnormalities account for 12% to 14% of all
live-born cases and 20% to 33% of fetal cases of congenital CVMs, indicating that the proper
genetic control of cardiac development is Disclosure: The authors have nothing to disclose.
Funding: Supported in part by Riley Children's Foundation, Showalter Trust, Center of …