Volume‐targeted versus pressure‐limited ventilation in neonates
C Klingenberg, KI Wheeler, N McCallion… - Cochrane Database …, 2017 - cochranelibrary.com
Cochrane Database of Systematic Reviews, 2017•cochranelibrary.com
Background Damage caused by lung overdistension (volutrauma) has been implicated in
the development of bronchopulmonary dysplasia (BPD). Modern neonatal ventilation modes
can target a set tidal volume as an alternative to traditional pressure‐limited ventilation
(PLV) using a fixed inflation pressure. Volume‐targeted ventilation (VTV) aims to produce a
more stable tidal volume in order to reduce lung damage and stabilise the partial pressure of
carbon dioxide (pCO 2). Objectives To determine whether VTV compared with PLV leads to …
the development of bronchopulmonary dysplasia (BPD). Modern neonatal ventilation modes
can target a set tidal volume as an alternative to traditional pressure‐limited ventilation
(PLV) using a fixed inflation pressure. Volume‐targeted ventilation (VTV) aims to produce a
more stable tidal volume in order to reduce lung damage and stabilise the partial pressure of
carbon dioxide (pCO 2). Objectives To determine whether VTV compared with PLV leads to …
Background
Damage caused by lung overdistension (volutrauma) has been implicated in the development of bronchopulmonary dysplasia (BPD). Modern neonatal ventilation modes can target a set tidal volume as an alternative to traditional pressure‐limited ventilation (PLV) using a fixed inflation pressure. Volume‐targeted ventilation (VTV) aims to produce a more stable tidal volume in order to reduce lung damage and stabilise the partial pressure of carbon dioxide (pCO 2).
Objectives
To determine whether VTV compared with PLV leads to reduced rates of death and death or BPD in newborn infants and to determine whether use of VTV affected outcomes including air leak, cranial ultrasound findings and neurodevelopment.
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