Involvement of histone H3 lysine 9 (H3K9) methyltransferase G9a in the maintenance of HIV-1 latency and its reactivation by BIX01294
K Imai, H Togami, T Okamoto - Journal of Biological Chemistry, 2010 - jbc.org
Elucidating the mechanism of human immunodeficiency virus, type 1 (HIV-1) provirus
transcriptional silencing in latently infected cells is crucial for understanding the
pathophysiological process of HIV-1 infection. It is well established that hypoacetylation of
histone proteins by histone deacetylases is involved in the maintenance of HIV-1 latency by
repressing viral transcription. Although histone methylation is involved in the organization of
chromatin domains and plays a central epigenetic role in gene expression, the role of …
transcriptional silencing in latently infected cells is crucial for understanding the
pathophysiological process of HIV-1 infection. It is well established that hypoacetylation of
histone proteins by histone deacetylases is involved in the maintenance of HIV-1 latency by
repressing viral transcription. Although histone methylation is involved in the organization of
chromatin domains and plays a central epigenetic role in gene expression, the role of …
