Calcium-sensing receptor (CaSR): pharmacological properties and signaling pathways
AD Conigrave, DT Ward - Best practice & research Clinical endocrinology & …, 2013 - Elsevier
In this article we consider the mechanisms by which the calcium-sensing receptor (CaSR)
induces its cellular responses via the control (activation or inhibition) of signaling pathways.
We consider key features of CaSR-mediated signaling including its control of the
heterotrimeric G-proteins G q/11, G i/o and G 12/13 and the downstream consequences
recognizing that very few CaSR-mediated cell phenomena have been fully described. We
also consider the manner in which the CaSR contributes to the formation of specific …
induces its cellular responses via the control (activation or inhibition) of signaling pathways.
We consider key features of CaSR-mediated signaling including its control of the
heterotrimeric G-proteins G q/11, G i/o and G 12/13 and the downstream consequences
recognizing that very few CaSR-mediated cell phenomena have been fully described. We
also consider the manner in which the CaSR contributes to the formation of specific …