Primary role for endoplasmic reticulum-bound ribosomes in cellular translation identified by ribosome profiling
DW Reid, CV Nicchitta - Journal of Biological Chemistry, 2012 - jbc.org
In eukaryotic cells, the spatial regulation of protein expression is frequently conferred
through the coupling of mRNA localization and the local control of translation. mRNA
localization to the endoplasmic reticulum (ER) is a prominent example of such regulation
and serves a ubiquitous role in segregating the synthesis of secretory and integral
membrane proteins to the ER. Recent genomic and biochemical studies have now
expanded this view to suggest a more substantial role for the ER cellular protein synthesis …
through the coupling of mRNA localization and the local control of translation. mRNA
localization to the endoplasmic reticulum (ER) is a prominent example of such regulation
and serves a ubiquitous role in segregating the synthesis of secretory and integral
membrane proteins to the ER. Recent genomic and biochemical studies have now
expanded this view to suggest a more substantial role for the ER cellular protein synthesis …
