Myopathy: five new things
B Oskarsson - Neurology, 2011 - AAN Enterprises
Neurology, 2011•AAN Enterprises
Neurology: Clinical Practice 76 (Suppl 2) February 15, 2011 S15 domyolysis have also
occurred with statin therapy; these are far less frequent but can possibly be fatal. Given the
prevalence of statin use, other myopathies also affect statin users. If symptoms of a
presumably statin-induced myopathy are severe, atypical, or do not resolve quickly with
discontinuation of statin treatment, then a more extensive workup including EMG and a
muscle biopsy is indicated. The changes that can be seen on muscle histology that are most …
occurred with statin therapy; these are far less frequent but can possibly be fatal. Given the
prevalence of statin use, other myopathies also affect statin users. If symptoms of a
presumably statin-induced myopathy are severe, atypical, or do not resolve quickly with
discontinuation of statin treatment, then a more extensive workup including EMG and a
muscle biopsy is indicated. The changes that can be seen on muscle histology that are most …
Neurology: Clinical Practice 76 (Suppl 2) February 15, 2011 S15 domyolysis have also occurred with statin therapy; these are far less frequent but can possibly be fatal. Given the prevalence of statin use, other myopathies also affect statin users. If symptoms of a presumably statin-induced myopathy are severe, atypical, or do not resolve quickly with discontinuation of statin treatment, then a more extensive workup including EMG and a muscle biopsy is indicated. The changes that can be seen on muscle histology that are most typical of a statin myopathy are cytochrome oxidase negative fibers, increased lipid content, and ragged red fibers. 6
American Academy of Neurology