Changes in mast‐cell distribution in skeletal muscle after denervation

G Sánchez‐Mejorada… - Muscle & Nerve: Official …, 1992 - Wiley Online Library
G Sánchez‐Mejorada, F Alonso‐deFlorida
Muscle & Nerve: Official Journal of the American Association of …, 1992Wiley Online Library
Motor nerves are known to govern the structure of skeletal muscle. In the normal guniea pig
diaphragmatic muscle, we found that mast cells were predominatly located in the central
tendon. Following denervation, these cells became more numerous in the muscle itself than
in the tendon. There fore, nervous trophic influences are exerted on other tissue elements
besides those which sustain transmission and contraction. Ascertaining mastcell distribution
in biopsies may help to elucidate denervation effects in motor neuron diseases.
Abstract
Motor nerves are known to govern the structure of skeletal muscle. In the normal guniea pig diaphragmatic muscle, we found that mast cells were predominatly located in the central tendon. Following denervation, these cells became more numerous in the muscle itself than in the tendon. There fore, nervous trophic influences are exerted on other tissue elements besides those which sustain transmission and contraction. Ascertaining mastcell distribution in biopsies may help to elucidate denervation effects in motor neuron diseases.
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