[HTML][HTML] Measles immunity and immunosuppression
DE Griffin - Current opinion in virology, 2021 - Elsevier
Highlights•Measles virus replication in lymphoid tissue uses CD150 as a B and T cell
receptor.•Persistent RNA in lymphoid tissue is associated with generation of durable
immunity.•Germinal centers and numbers of peripheral Tfh cells and antibody-secreting cells
increase for months.•Increased susceptibility to other infections continues for years after
apparent recovery.•Memory and naïve B cells are depleted and diversity of pre-existing
antibodies is reduced.Effects of measles on the immune system are only partially …
receptor.•Persistent RNA in lymphoid tissue is associated with generation of durable
immunity.•Germinal centers and numbers of peripheral Tfh cells and antibody-secreting cells
increase for months.•Increased susceptibility to other infections continues for years after
apparent recovery.•Memory and naïve B cells are depleted and diversity of pre-existing
antibodies is reduced.Effects of measles on the immune system are only partially …
