The CD163-expressing macrophages recognize and internalize TWEAK: potential consequences in atherosclerosis

JA Moreno, B Muñoz-García, JL Martín-Ventura… - Atherosclerosis, 2009 - Elsevier
BACKGROUND: CD163 is a new potential scavenger receptor of Tumor necrosis factor-like
weak inducer of apoptosis (TWEAK) which elicits diverse biologic actions involved in
atherosclerosis. We have analyzed the importance of TWEAK–CD163 interaction in
atherosclerosis. METHODS: TWEAK and CD163 interaction was studied in cultured human
macrophages. Moreover, TWEAK and CD163 expression was analyzed in carotid
atherosclerotic plaques (immunohistochemistry) and plasma (ELISA). We have also …