Identification of the humanklothogene and its two transcripts encoding membrane and secretedklothoprotein
Y Matsumura, H Aizawa, T Shiraki-Iida, R Nagai… - Biochemical and …, 1998 - Elsevier
Y Matsumura, H Aizawa, T Shiraki-Iida, R Nagai, M Kuro-o, Y Nabeshima
Biochemical and biophysical research communications, 1998•ElsevierInactivation of theklotho (kl) gene in mice results in multiple disorders that resemble human
aging. The mouseklgene encodes a novel single-pass membrane protein with homology to
β-glucosidases. In this study, we have isolated a human homologue of theklgene and
determined its gene structure. The humanklgene is composed of 5 exons and ranges over
50 kb on chromosome 13q12. We have further identified two transcripts that encode a
membrane or secreted protein. These transcripts arise from a singleklgene through …
aging. The mouseklgene encodes a novel single-pass membrane protein with homology to
β-glucosidases. In this study, we have isolated a human homologue of theklgene and
determined its gene structure. The humanklgene is composed of 5 exons and ranges over
50 kb on chromosome 13q12. We have further identified two transcripts that encode a
membrane or secreted protein. These transcripts arise from a singleklgene through …
Inactivation of theklotho(kl) gene in mice results in multiple disorders that resemble human aging. The mouseklgene encodes a novel single-pass membrane protein with homology to β-glucosidases. In this study, we have isolated a human homologue of theklgene and determined its gene structure. The humanklgene is composed of 5 exons and ranges over 50 kb on chromosome 13q12. We have further identified two transcripts that encode a membrane or secreted protein. These transcripts arise from a singleklgene through alternative RNA splicing. Expression of the putative secreted form predominates over that of the membrane form. The present study provides fundamental information necessary for further analyses of the humanklgene and its functions.
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