Initial FGF23-mediated signaling occurs in the distal convoluted tubule
EG Farrow, SI Davis, LJ Summers… - Journal of the American …, 2009 - journals.lww.com
Abstract Fibroblast growth factor-23 (FGF23), a hormone central to phosphate and vitamin D
metabolism, reduces renal absorption of phosphate by downregulating the sodium-
phosphate cotransporter Npt2a. However, the mechanisms of FGF23 action in the kidney
are unclear, as Npt2a localizes to the proximal tubule (PT) and the FGF23 coreceptor α-
Klotho (KL) localizes to the distal convoluted tubule (DCT). Immunofluorescent analyses
following FGF23 injection in mice showed robust staining for phospho-ERK1/2, a marker of …
metabolism, reduces renal absorption of phosphate by downregulating the sodium-
phosphate cotransporter Npt2a. However, the mechanisms of FGF23 action in the kidney
are unclear, as Npt2a localizes to the proximal tubule (PT) and the FGF23 coreceptor α-
Klotho (KL) localizes to the distal convoluted tubule (DCT). Immunofluorescent analyses
following FGF23 injection in mice showed robust staining for phospho-ERK1/2, a marker of …