High levels of circulating IL-8 and soluble IL-2R are associated with prolonged illness in patients with severe COVID-19
A Ma, L Zhang, X Ye, J Chen, J Yu, L Zhuang… - Frontiers in …, 2021 - frontiersin.org
Frontiers in immunology, 2021•frontiersin.org
Objectives The coordinated immune response of the host is the key of the successful combat
of the body against SARS-CoV-2 infection and is decisive for the development and
progression of COVID-19. In this study, we aimed to investigate whether the immunological
phenotype of patients are associated with duration of illness in patients with severe COVID-
19. Method In this single-center study, 69 patients with severe or critical COVID-19 were
recruited retrospectively. Immunological parameters including counts of white blood cells …
of the body against SARS-CoV-2 infection and is decisive for the development and
progression of COVID-19. In this study, we aimed to investigate whether the immunological
phenotype of patients are associated with duration of illness in patients with severe COVID-
19. Method In this single-center study, 69 patients with severe or critical COVID-19 were
recruited retrospectively. Immunological parameters including counts of white blood cells …
Objectives
The coordinated immune response of the host is the key of the successful combat of the body against SARS-CoV-2 infection and is decisive for the development and progression of COVID-19. In this study, we aimed to investigate whether the immunological phenotype of patients are associated with duration of illness in patients with severe COVID-19.
Method
In this single-center study, 69 patients with severe or critical COVID-19 were recruited retrospectively. Immunological parameters including counts of white blood cells, neutrophils, lymphocytes, the neutrophil-to-lymphocyte ratio, and levels of circulating cytokines and cytokine receptors were screened for their association with disease severity, survival and duration of illness of COVID-19.
Results
Our data confirmed previous results that neutrophil-to-lymphocyte ratio and circulating levels of IL-6 represent prominent biomarker for the prediction of disease severity and survival of COVID-19. However, this study shows for the first time that duration of illness in patients with severe COVID-19 is positively associated with serum levels of IL-8 (P=0.004) and soluble IL-2Rα (P=0.025).
Conclusion
The significant association of duration of illness with circulating levels of IL-8 and soluble IL-2Rα in patients with severe COVID-19 implicates that neutrophils and T cells are involved in the evolution of COVID-19.
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