Role of the C terminus of the interleukin 8 receptor in signal transduction and internalization
GN Prado, H Suzuki, N Wilkinson, B Cousins… - Journal of Biological …, 1996 - jbc.org
Interleukin 8 (IL-8) is a potent neutrophil chemoattractant and activator. Two IL-8 receptor
subtypes, A and B, are expressed in neutrophils. In this work, we analyzed the role of the C
terminus domain of the IL-8 receptor on the signal transduction and receptor internalization
mechanisms. The IL-8 receptor A was tagged with an epitope corresponding to the
monoclonal antibody 1D4 to monitor the localization of the IL-8 receptor. We demonstrated
IL-8-dependent receptor internalization by monitoring the density of surface 125 I-labeled IL …
subtypes, A and B, are expressed in neutrophils. In this work, we analyzed the role of the C
terminus domain of the IL-8 receptor on the signal transduction and receptor internalization
mechanisms. The IL-8 receptor A was tagged with an epitope corresponding to the
monoclonal antibody 1D4 to monitor the localization of the IL-8 receptor. We demonstrated
IL-8-dependent receptor internalization by monitoring the density of surface 125 I-labeled IL …