Connective tissue growth factor (CCN2) in blood vessels
M Ponticos - Vascular pharmacology, 2013 - Elsevier
The CCN family comprise the products of six immediate-early response genes (Cyr61, Ctgf,
Nov and Wisp1-3) and are multi-functional proteins, characterised by four discrete protein
modules in which reside functional domains: an insulin-like growth factor binding protein-
like module (IGFBP) but has low affinity for IGFBPs, a von Willebrand factor type C repeat
module (VWC) which mediates integrin and growth factor binding, a thrombospondin type-1
repeat module (TSP-1), and a cysteine-knot-containing module (CT). These modules …
Nov and Wisp1-3) and are multi-functional proteins, characterised by four discrete protein
modules in which reside functional domains: an insulin-like growth factor binding protein-
like module (IGFBP) but has low affinity for IGFBPs, a von Willebrand factor type C repeat
module (VWC) which mediates integrin and growth factor binding, a thrombospondin type-1
repeat module (TSP-1), and a cysteine-knot-containing module (CT). These modules …