The CCN family: a new class of inflammation modulators?
L Kular, J Pakradouni, P Kitabgi, M Laurent… - Biochimie, 2011 - Elsevier
Uncontrolled or sustained inflammation is the underlying cause of or actively contributes to
the progression of many chronic pathologies such as atherosclerosis, arthritis, or
neuroinflammatory diseases. Matricellular proteins of the CCN family (CYR61/CTGF/NOV)
have emerged as localized multitasking signal integrators. These structurally conserved
secreted proteins specifically interact with and signal through various extracellular partners,
in particular integrins, which enable them to play crucial roles in various processes including …
the progression of many chronic pathologies such as atherosclerosis, arthritis, or
neuroinflammatory diseases. Matricellular proteins of the CCN family (CYR61/CTGF/NOV)
have emerged as localized multitasking signal integrators. These structurally conserved
secreted proteins specifically interact with and signal through various extracellular partners,
in particular integrins, which enable them to play crucial roles in various processes including …