Oxidative stress plays a critical role in the pathogenesis of atherosclerosis including the
formation of lipid laden macrophages and the development of inflammation. However,
oxidative stress-induced molecular signaling that regulates the development of vascular
calcification has not been investigated in depth. Osteogenic differentiation of vascular
smooth muscle cells (VSMC) is critical in the development of calcification in atherosclerotic
lesions. An important contributor to oxidative stress in atherosclerotic lesions is the formation …