B cells under influence: transformation of B cells by Epstein–Barr virus
R Küppers - Nature Reviews Immunology, 2003 - nature.com
Nature Reviews Immunology, 2003•nature.com
Epstein–Barr virus (EBV) is an extremely successful virus, infecting more than 90% of the
human population worldwide. After primary infection, the virus persists for the life of the host,
usually as a harmless passenger residing in B cells. However, EBV can transform B cells,
which can result in the development of malignant lymphomas. Intriguingly, the three main
types of EBV-associated B-cell lymphoma—that is, Burkitt lymphoma, Hodgkin lymphoma
and post-transplant lymphomas—seem to derive from germinal-centre B cells or atypical …
human population worldwide. After primary infection, the virus persists for the life of the host,
usually as a harmless passenger residing in B cells. However, EBV can transform B cells,
which can result in the development of malignant lymphomas. Intriguingly, the three main
types of EBV-associated B-cell lymphoma—that is, Burkitt lymphoma, Hodgkin lymphoma
and post-transplant lymphomas—seem to derive from germinal-centre B cells or atypical …
Abstract
Epstein–Barr virus (EBV) is an extremely successful virus, infecting more than 90% of the human population worldwide. After primary infection, the virus persists for the life of the host, usually as a harmless passenger residing in B cells. However, EBV can transform B cells, which can result in the development of malignant lymphomas. Intriguingly, the three main types of EBV-associated B-cell lymphoma — that is, Burkitt lymphoma, Hodgkin lymphoma and post-transplant lymphomas — seem to derive from germinal-centre B cells or atypical survivors of the germinal-centre reaction in most, if not all, cases, indicating that EBV-infected germinal-centre B cells are at particular risk for malignant transformation.
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