Identification and characterization of S2V, a novel putative siglec that contains two V set Ig-like domains and recruits protein-tyrosine phosphatases SHPs
Z Yu, CM Lai, M Maoui, D Banville, SH Shen - Journal of Biological …, 2001 - jbc.org
We describe the molecular cloning and characterization of S2V, a novel sialic acid binding
immunoglobulin-like lectin. The cDNA of S2V encodes a type 1 transmembrane protein with
four extracellular immunoglobulin-like (Ig-like) domains and a cytoplasmic tail bearing a
typical immunoreceptor tyrosine-based inhibitory motif (ITIM) and an ITIM-like motif. A
unique feature of S2V is the presence of two V-set Ig-like domains responsible for the
binding to sialic acid, whereas all other known siglecs possess only one. S2V is …
immunoglobulin-like lectin. The cDNA of S2V encodes a type 1 transmembrane protein with
four extracellular immunoglobulin-like (Ig-like) domains and a cytoplasmic tail bearing a
typical immunoreceptor tyrosine-based inhibitory motif (ITIM) and an ITIM-like motif. A
unique feature of S2V is the presence of two V-set Ig-like domains responsible for the
binding to sialic acid, whereas all other known siglecs possess only one. S2V is …
