Serum 24, 25-dihydroxyvitamin D3 response to native vitamin D2 and D3 supplementation in patients with chronic kidney disease on hemodialysis
LA Graeff-Armas, M Kaufmann, E Lyden, G Jones - Clinical nutrition, 2018 - Elsevier
Background & aims While vitamin D deficiency is common in patients with end stage renal
disease on dialysis and treatment with Vitamin D 2 and Vitamin D 3 is becoming
increasingly common in these patients, little is known about 24, 25 (OH) 2 D 3 metabolite
production. Some authors report that the CYP24A1 enzyme is upregulated in CKD, but
reports of low serum levels of 24, 25 (OH) 2 D 3 in these patients bring this into question.
Lack of substrate or increased clearance of the metabolite have been proposed as possible …
disease on dialysis and treatment with Vitamin D 2 and Vitamin D 3 is becoming
increasingly common in these patients, little is known about 24, 25 (OH) 2 D 3 metabolite
production. Some authors report that the CYP24A1 enzyme is upregulated in CKD, but
reports of low serum levels of 24, 25 (OH) 2 D 3 in these patients bring this into question.
Lack of substrate or increased clearance of the metabolite have been proposed as possible …
