Single-cell sequencing reveals clonal expansions of pro-inflammatory synovial CD8 T cells expressing tissue-homing receptors in psoriatic arthritis
F Penkava, MDC Velasco-Herrera, MD Young… - Nature …, 2020 - nature.com
Nature communications, 2020•nature.com
Psoriatic arthritis (PsA) is a debilitating immune-mediated inflammatory arthritis of unknown
pathogenesis commonly affecting patients with skin psoriasis. Here we use complementary
single-cell approaches to study leukocytes from PsA joints. Mass cytometry demonstrates a
3-fold expansion of memory CD8 T cells in the joints of PsA patients compared to peripheral
blood. Meanwhile, droplet-based and plate-based single-cell RNA sequencing of paired T
cell receptor alpha and beta chain sequences show pronounced CD8 T cell clonal …
pathogenesis commonly affecting patients with skin psoriasis. Here we use complementary
single-cell approaches to study leukocytes from PsA joints. Mass cytometry demonstrates a
3-fold expansion of memory CD8 T cells in the joints of PsA patients compared to peripheral
blood. Meanwhile, droplet-based and plate-based single-cell RNA sequencing of paired T
cell receptor alpha and beta chain sequences show pronounced CD8 T cell clonal …
Abstract
Psoriatic arthritis (PsA) is a debilitating immune-mediated inflammatory arthritis of unknown pathogenesis commonly affecting patients with skin psoriasis. Here we use complementary single-cell approaches to study leukocytes from PsA joints. Mass cytometry demonstrates a 3-fold expansion of memory CD8 T cells in the joints of PsA patients compared to peripheral blood. Meanwhile, droplet-based and plate-based single-cell RNA sequencing of paired T cell receptor alpha and beta chain sequences show pronounced CD8 T cell clonal expansions within the joints. Transcriptome analyses find these expanded synovial CD8 T cells to express cycling, activation, tissue-homing and tissue residency markers. T cell receptor sequence comparison between patients identifies clonal convergence. Finally, chemokine receptor CXCR3 is upregulated in the expanded synovial CD8 T cells, while two CXCR3 ligands, CXCL9 and CXCL10, are elevated in PsA synovial fluid. Our data thus provide a quantitative molecular insight into the cellular immune landscape of psoriatic arthritis.
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