Nicotinic acid (NiAc) is a potent inhibitor of lipolysis, acutely reducing plasma free fatty acid
(FFA) concentrations. However, a major FFA rebound is seen during rapid NiAc washout,
and sustained exposure is associated with tolerance development, with FFAs returning to
pretreatment levels. Our aim was to find a rational NiAc dosing regimen that preserves FFA
lowering, sufficient to reverse nonadipose tissue lipid accumulation and improve metabolic
control, in obese Zucker rats. We compared feeding-period versus fasting-period NiAc …