Activation of the succinate receptor GPR91 in macula densa cells causes renin release

SL Vargas, JJ Kang, EJ Meer - Journal of the American Society …, 2009 - journals.lww.com
Macula densa (MD) cells of the juxtaglomerular apparatus (JGA) are salt sensors and
generate paracrine signals that control renal blood flow, glomerular filtration, and release of
the prohypertensive hormone renin. We hypothesized that the recently identified succinate
receptor GPR91 is present in MD cells and regulates renin release. Using
immunohistochemistry, we identified GPR91 in the apical plasma membrane of MD cells.
Treatment of MD cells with succinate activated mitogen-activated protein kinases (MAPKs; …