The G protein–coupled succinate and α-ketoglutarate receptors are closely related to the
family of P2Y purinoreceptors. Although the α-ketoglutarate receptor is almost exclusively
expressed in the kidney, its function is unknown. In contrast, the succinate receptor,
SUCRN1, is expressed in a variety of tissues, including blood cells, adipose tissue, liver,
retina, and the kidney. Recent evidence suggests SUCRN1 and its succinate ligand are
novel detectors of local stress, including ischemia, hypoxia, toxicity, and hyperglycemia …