[HTML][HTML] Lactate inhibits lipolysis in fat cells through activation of an orphan G-protein-coupled receptor, GPR81
C Liu, J Wu, J Zhu, C Kuei, J Yu, J Shelton… - Journal of Biological …, 2009 - ASBMB
Lactic acid is a well known metabolic by-product of intense exercise, particularly under
anaerobic conditions. Lactate is also a key source of energy and an important metabolic
substrate, and it has also been hypothesized to be a signaling molecule directing metabolic
activity. Here we show that GPR81, an orphan G-protein-coupled receptor highly expressed
in fat, is in fact a sensor for lactate. Lactate activates GPR81 in its physiological
concentration range of 1–20 mm and suppresses lipolysis in mouse, rat, and human …
anaerobic conditions. Lactate is also a key source of energy and an important metabolic
substrate, and it has also been hypothesized to be a signaling molecule directing metabolic
activity. Here we show that GPR81, an orphan G-protein-coupled receptor highly expressed
in fat, is in fact a sensor for lactate. Lactate activates GPR81 in its physiological
concentration range of 1–20 mm and suppresses lipolysis in mouse, rat, and human …